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Ayahuasca, a concoction used for centuries by indigenous Amazon tribes, contains the powerful psychedelic drug dimethyltryptamine (DMT) and monoamine oxidase inhibitors. The brew is typically prepared using leaves from the Psychotria viridis shrub and the bark of the Banisteriopsis caapi vine. Consuming a single dose of the psychedelic brew ayahuasca can result in lasting changes in higher-order cognitive brain networks. The psychedelic experience induced by ayahuasca has a long-lasting effect on the functional organization of brain networks supporting higher order cognitive and affective functions.
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